Mayer, Bjoern and Lieb, Wolfgang and Radke, Peter W. and Goetz, Anika and Fischer, Marcus and Baessler, Andrea and Doehring, Lars C. and Aherrahrou, Zouhair and Liptau, Henrike and Erdmann, Jeanette and Holmer, Stephan and Hense, Hans-Werner and Hengstenberg, Christian and Schunkert, Heribert (2007) Association between arterial pressure and coronary artery calcification. JOURNAL OF HYPERTENSION, 25 (8). pp. 1731-1738. ISSN 0263-6352,
Full text not available from this repository. (Request a copy)Abstract
Objectives Coronary artery calcification (CAC) determined by electron beam computed tomography is a predictor of future cardiovascular events. This study investigates conditions affecting CAC severity in patients with coronary artery disease (CAD) undergoing coronary angiography. Methods Presence and degree of CAC were assessed angiographically in 877 CAD patients grouped into no visible CAC (n = 333), mild to moderate CAC (n = 321), and severe CAC (n = 223). Regression analyses investigated relationships between CAC and demographic data, cardiovascular risk factors, and coronary anatomy. Results Prevalences of hypertension and systolic blood pressure (SBP) values were higher in individuals with CAC (moderate CAC: 49.5%, 137.5 +/- 18.6 mmHg; severe CAC: 58.3%, 142.1 +/- 20.4 mmHg) compared to individuals with CAD but no CAC (42.0%, 134.0 +/- 18.4 mmHg; both P<0.001). Likewise, pulse pressure was significantly elevated with increasing degree of CAC (no CAC, 52.3 +/- 13.6 mmHg vs moderate CAC, 55.7 +/- 14.4 mmHg vs severe CAC, 59.1 +/- 15.4 mmHg; P<0.001). Further determinants of CAC were age, positive family history for CAC and severity of CAD. No differences in CAC severity were found in relation to body mass index, low-density lipoprotein-cholesterol, diabetes, and smoking habits. In multivariate analysis, CAC was independently related to age, SBP or pulse pressure, respectively, positive family history for CAC, and the severity of CAD. Conclusions Of the cardiovascular risk factors, SBP and pulse pressure display the strongest relationship with angiographic detection of CAC. Mechanistic studies need to clarify whether hypertension causes CAC, or whether coronary calcium deposition serves as a marker for a higher degree of vascular calcification and, thus, impaired vascular compliance and higher blood pressure levels.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BEAM COMPUTED-TOMOGRAPHY; MYOCARDIAL-INFARCTION; BLOOD-PRESSURE; PROGNOSTIC VALUE; ATHEROSCLEROTIC PLAQUE; RISK-FACTORS; DISEASE; CALCIUM; ADULTS; AGE; calcification; cardiovascular risk profile; coronary artery disease; myocardial infarction; pulse pressure; systolic blood pressure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Dec 2020 13:59 |
| Last Modified: | 02 Dec 2020 14:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32457 |
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