Hafner, Christian and Hartmann, Arndt and Real, Francisco X. and Hofstaedter, Ferdinand and Landthaler, Michael and Vogt, Thomas (2007) Spectrum of FGFR3 mutations in multiple intraindividual seborrheic keratoses. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 127 (8). pp. 1883-1885. ISSN 0022-202X,
Full text not available from this repository. (Request a copy)Abstract
Somatic FGFR3 mutations have recently been identified in seborrheic keratoses (SK). Affected individuals often show a large number of SK, but their spectrum of FGFR3 mutations has not been investigated yet. We analyzed 78 SK of four patients using a SNaPshot multiplex assay. FGFR3 mutations were detected in 46 of 78 SK (59%). The mutation rates of the patients ranged from 26 to 89%. Each patient showed at least four different mutated loci. FGFR3 mutations appear to be common genetic alterations in multiple SK with a varying interindividual mutation frequency but without specific intraindividual hot spots.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BENIGN SKIN TUMORS; ACTIVATING MUTATIONS; GROWTH; BLADDER; CRANIOSYNOSTOSIS; ACHONDROPLASIA; FREQUENCY; EXPOSURE; SUNLIGHT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Dec 2020 13:39 |
| Last Modified: | 01 Dec 2020 13:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32458 |
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