Hafner, Christian and Hartmann, Arndt and van Oers, Johanna M. M. and Stoehr, Robert and Zwarthoff, Ellen C. and Hofstaedter, Ferdinand and Landthaler, Michael and Vogt, Thomas (2007) FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization. MODERN PATHOLOGY, 20 (8). pp. 895-903. ISSN 0893-3952, 1530-0285
Full text not available from this repository. (Request a copy)Abstract
Somatic activating fibroblast growth factor 3 (FGFR3) mutations in human skin can cause seborrheic keratoses, one of the most frequent skin tumors in man. However, details of the involved mechanisms remain elusive. We analyzed 65 acanthotic seborrheic keratoses with varying vertical diameters for FGFR3 mutations using a SNaPshot (R) multiplex assay. Immunohistochemistry was performed for Ki-67, bcl-2 and FGFR3 protein in all seborrheic keratoses and 19 normal skin samples. FGFR3 mutations were detected in 37 of 65 seborrheic keratoses (57%). These mutations were found both in flat ( initial) and thick seborrheic keratoses. FGFR3 mutations were significantly associated with increased age and localization on the head and neck (P < 0.01). Ki-67 expression was significantly higher in seborrheic keratoses than in normal epidermis independent of the FGFR3 status (P < 0.001). Furthermore, FGFR3 mutations were associated with an increased expression of bcl-2 and FGFR3 protein (P < 0.05). Our results indicate that FGFR3 mutations can occur early in the pathogenesis of at least a subset of seborrheic keratoses. Increased age appears to be a risk factor for these mutations. The preferential occurrence of FGFR3 mutations in seborrheic keratoses of the head and neck suggests a causative role for cumulative lifetime ultraviolet light exposure.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR RECEPTOR-3; BENIGN SKIN TUMORS; ACTIVATING MUTATIONS; CARCINOMAS; ACHONDROPLASIA; FREQUENCY; APOPTOSIS; SUNLIGHT; BLADDER; seborrheic keratosis; acanthosis; FGFR3 mutation; bcl-2; Ki-67 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Dec 2020 13:41 |
| Last Modified: | 01 Dec 2020 13:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32466 |
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