Dornseifer, U. and Matiasek, K. and Fichter, M. A. and Rupp, A. and Henke, J. and Weldner, N. and Kovacs, L. and Schmahl, W. and Blemer, E. and Ninkovic, M. and Papadopulos, N. A. (2007) Surgical therapy of peripheral nerve lesions: Current status and new perspectives. ZENTRALBLATT FUR NEUROCHIRURGIE, 68 (3). pp. 101-110. ISSN 0044-4251
Full text not available from this repository. (Request a copy)Abstract
The severe functional deficits in patients suffering from traumatic peripheral nerve damage underline the necessity of an optimal therapy. The development of microsurgical techniques in the sixties contributed significantly to the progress in nerve repair. Since then, no major clinical innovation has become established. However, with an increased understanding of cellular and molecular mechanisms underlying nerve regeneration, various tubulization concepts have been developed which yield possible alternatives to direct suturing and to autologous nerve grafting in cases of short nerve defects. The vast knowledge gathered in the field of nerve regeneration needs to be further exploited in order to develop alternative therapeutic strategies to nerve autografting, which can result in donor-site defects and often lead to inappropriate results. Considering the encouraging results from preclinical studies, innovative nerve repair strategies are likely to improve the outcome of reconstructive surgical interventions. This paper outlines, in addition to the fundamentals of nerve regeneration, the current treatment options for defects of peripheral nerves. This article also reviews the developments in the use of alternative nerve guides and demonstrates new perspectives in the field of peripheral nerve reconstruction.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR RECEPTOR; RAT SCIATIC-NERVE; DENATURED MUSCLE-TISSUE; MONKEY MEDIAN NERVE; VEIN GRAFT REPAIR; SCHWANN-CELLS; NEUROTROPHIC FACTOR; COLLAGEN FILAMENTS; AXONAL ELONGATION; HUMAN FOREARM; nerve regeneration; nerve reconstruction; nerve graft; nerve conduits; nerve healing; tissue engineering |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 30 Oct 2020 10:10 |
| Last Modified: | 30 Oct 2020 10:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32492 |
Actions (login required)
 |
View Item |
