Babilas, P. and Knobler, R. and Hummel, S. and Gottschaller, C. and Maisch, T. and Koller, M. and Landthaler, M. and Szeimies, R.-M. (2007) Variable pulsed light is less painful than light-emitting diodes for topical photodynamic therapy of actinic keratosis: a prospective randomized controlled trial. BRITISH JOURNAL OF DERMATOLOGY, 157 (1). pp. 111-117. ISSN 0007-0963,
Full text not available from this repository. (Request a copy)Abstract
Background Photodynamic therapy (PDT) of actinic keratosis (AK) using methylaminolaevulinate (MAL) is an effective and safe treatment option, but the procedure is painful. Objectives To evaluate the efficacy and pain associated with variable pulsed light (VPL), a prospective, randomized, controlled split-face study was performed. Methods Topical MAL-PDT was conducted in 25 patients with AK (n = 238) who were suitable for two-sided comparison. After incubation with MAL, irradiation was performed with a light-emitting diode (LED) (50 mW cm(-2); 37 J cm(-2)) vs. VPL (80 J cm(-2), double pulsed at 40 J cm(-2), pulse train of 15 impulses each with a duration of 5 ms, 610-950 nm filtered hand piece) followed by re-evaluation up to 3 months. Results The pain during and after therapy was significantly lower with VPL irradiation [t (d.f. = 24) = 4.42, P < 0.001]. The overall mean +/- SD infiltration and keratosis score at 3 months after treatment was 0.86 +/- 0.71 (LED system) vs. 1.05 +/- 0.74 (VPL device) (no statistically significant difference; P = 0.292). Patient satisfaction following both treatment modalities did not significantly differ at the 3-month follow up (P = 0.425). Conclusions VPL used for MAL-PDT is an efficient alternative for the treatment of AK that results in complete remission and cosmesis equivalent to LED irradiation but causes significantly less pain.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DELTA-AMINOLEVULINIC-ACID; 5-AMINOLEVULINIC ACID; IN-VIVO; SOLAR KERATOSES; LASER; SKIN; LESIONS; METHYLESTER; DERMATOLOGY; VITRO; 5-aminolaevulinic acid; actinic keratosis; photodynamic therapy; protoporphyrin IX; randomized controlled trial |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Dec 2020 11:42 |
| Last Modified: | 02 Dec 2020 11:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32525 |
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