Moser, Christian and Lang, Sven A. and Stoeltzing, Oliver (2007) The direct effects of anti-vascular endothelial growth factor therapy on tumor cells. CLINICAL COLORECTAL CANCER, 6 (8). pp. 564-571. ISSN 1533-0028
Full text not available from this repository. (Request a copy)Abstract
The vascular endothelial growth factor (VEGF) family members are essential mediators of tumor angiogenesis. The multiple functions of the VEGFs are mediated through complex interactions between their ligands, the high-affinity tyrosine kinase receptors, and co-receptors (neuropilins). Emerging evidence has shown that these receptors, formerly described as being exclusively expressed on endothelial cells, are also expressed on a number of nonendothelial cells, including tumor cells. Moreover, it has been shown that their receptors (VEGFRs) are functional in a number of nonendothelial systems, where they can serve as targets for anti-VEGF therapy. As the expression of VEGFRs on tumor cells contributes to the understanding of the complex roles of VEGF within the tumor microenvironment and elucidation of VEGF activity might further refine antineoplastic regimens, this article will review the main effects and selective interactions of the VEGFRs, the evidence for their expression and function on tumor cells, and the direct efforts of anti-VEGF therapy on tumor cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | METASTATIC COLORECTAL-CANCER; HUMAN PANCREATIC-CANCER; PHASE-II TRIAL; RECEPTOR TYROSINE KINASES; LIGAND VEGF-C; BREAST-CANCER; PROGNOSTIC VALUE; CARCINOMA CELLS; GASTRIC-CANCER; HEMATOLOGIC MALIGNANCIES; angiogenesis; neuropilins; placental growth factor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 30 Oct 2020 09:27 |
| Last Modified: | 30 Oct 2020 09:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32526 |
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