Veenema, Alexa H. and de Kloet, E. R. and de Wilde, M. C. and Roelofs, A. J. and Kawata, M. and Buwalda, B. and Neumann, I. D. and Koolhaas, J. M. and Lucassen, P. J. (2007) Differential effects of stress on adult hippocampal cell proliferation in low and high aggressive mice. JOURNAL OF NEUROENDOCRINOLOGY, 19 (7). pp. 489-498. ISSN 0953-8194,
Full text not available from this repository. (Request a copy)Abstract
Male wild house mice selected for a long (LAL) or a short (SAL) latency to attack a male intruder generally show opposing behavioural coping responses to environmental challenges. LAL mice, unlike SAL mice, adapt to novel challenges with a highly reactive hypothalamic-pituitary-adrenal axis and show an enhanced expression of markers for hippocampal plasticity. The present study aimed to test the hypothesis that these features of the more reactive LAL mice are reflected in parameters of hippocampal cell proliferation. The data show that basal cell proliferation in the subgranular zone (SGZ) of the dentate gyrus, assessed by the endogenous proliferation marker Ki-67, is lower in LAL than in SAL mice. Furthermore, application of bromodeoxyuridine (BrdU) over 3 days showed an almost two-fold lower cell proliferation rate in the SGZ in LAL versus SAL mice. Exposure to forced swimming resulted, 24 h later, in a significant reduction in BrdU + cell numbers in LAL mice, whereas cell proliferation was unaffected by this stressor in SAL mice. Plasma corticosterone and dentate gyrus glucocorticoid receptor levels were higher in LAL than in SAL mice. However, no differences between the SAL and LAL lines were found for hippocampal NMDA receptor binding. In conclusion, the data suggest a relationship between coping responses and hippocampal cell proliferation, in which corticosterone may be one of the determinants of line differences in cell proliferation responses to environmental challenges.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RAT DENTATE GYRUS; GLUCOCORTICOID RECEPTOR-IMMUNOREACTIVITY; NONAGGRESSIVE MALE-MICE; ACTIVE SHOCK AVOIDANCE; ATTACK LATENCY MICE; WILD HOUSE MICE; ENVIRONMENTAL ENRICHMENT; GENETIC INFLUENCE; PSYCHOSOCIAL STRESS; PROTEIN EXPRESSION; BrdU; coping style; dentate gyrus; hippocampal plasticity; neurogenesis |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Dec 2020 06:43 |
| Last Modified: | 07 Dec 2020 06:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32560 |
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