Hauser, Andrea and Hehlgans, Thomas and Maennel, Daniela N. (2007) Characterization of TNF receptor type 2 isoform in the mouse. MOLECULAR IMMUNOLOGY, 44 (14). pp. 3563-3570. ISSN 0161-5890,
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In this report a TNF receptor type 2 (TNFR2) isoform in the mouse, termed micp75TNFR, was compared to its human orthologue hicp75TNFR and to the known mouse TNFR2. The micp75TNFR is generated by the use of an alternative transcriptional start site within the mouse TNFR2 gene. This receptor isoform was found to be expressed in different macrophage-like and endothelial tumor cell lines and mouse spleen cells after stimulation. Lacking the leader sequence and part of the amino-terminal end of the mature TNFR2, the micp75TNFR was characterized by mainly intracellular expression. In contrast to its human paralogue, the micp75TNFR lacked the capacity to bind TNF. Therefore, micp75TNFR expression did not mediate protection from TNF-induced cytotoxicity but may interfere with TNFR2 signalling. (c) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; TNF RECEPTOR; FUNCTIONAL-CHARACTERIZATION; MOLECULAR-CLONING; EXPRESSION; LIGAND; CELLS; TNF receptor; isoform; cytotoxicity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Dec 2020 06:29 |
| Last Modified: | 03 Dec 2020 06:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32567 |
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