Quantifying fixation in patients with Stargardt disease

Reinhard, Jens and Messias, Andre and Dietz, Klaus and MacKeben, Manfred and Lakmann, Raimund and Scholl, Hendrik P. N. and Apfelstedt-Sylla, Eckart and Weber, Bernhard H. F. and Seeliger, Mathias W. and Zrenner, Eberhart and Trauzettel-Klosinski, Susanne (2007) Quantifying fixation in patients with Stargardt disease. VISION RESEARCH, 47 (15). pp. 2076-2085. ISSN 0042-6989,

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Abstract

Fixational eye movements in 60 eyes of 30 patients with ABCA4-associated Stargardt disease were recorded by a Scanning Laser Ophthalmoscope (SLO). The results were quantified by two new fixation quality measures expressing the eccentricity of the preferred retinal locus (PRL) non-parametrically, and fixation stability by a dynamic index. 46 eyes (77%) fixated eccentrically; in 32 eyes (70% of the eccentrically fixating eyes) the PRL was located above the central retinal lesion. PRL eccentricity correlated positively with logMAR visual acuity (r =.72; p <.0001) and negatively with fixation stability (r = -.58; p <.0001). Multiple PRL were found only in three eyes. (C) 2007 Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: SCANNING LASER OPHTHALMOSCOPE; PREFERRED RETINAL LOCI; MACULAR SCOTOMA; MONOCULAR FIXATION; LOCATION; DEGENERATION; STABILITY; FOVEA; TARGETS; FUNDUS; fixation stability; preferred retinal locus (PRL); Scanning Laser Ophthalmoscope (SLO); maculopathy; Stargardt disease
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Humangenetik
Depositing User: Dr. Gernot Deinzer
Date Deposited: 07 Dec 2020 07:00
Last Modified: 07 Dec 2020 07:00
URI: https://pred.uni-regensburg.de/id/eprint/32588

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