Sandrelli, Federica and Tauber, Eran and Pegoraro, Mirko and Mazzotta, Gabriella and Cisotto, Paola and Landskron, Johannes and Stanewsky, Ralf and Piccin, Alberto and Rosato, Ezio and Zordan, Mauro and Costa, Rodolfo and Kyriacou, Charalambos P. (2007) A molecular basis for natural selection at the timeless locus in Drosophila melanogaster. SCIENCE, 316 (5833). pp. 1898-1900. ISSN 0036-8075,
Full text not available from this repository. (Request a copy)Abstract
Diapause is a protective response to unfavorable environments that results in a suspension of insect development and is most often associated with the onset of winter. The ls-tim mutation in the Drosophila melanogaster clock gene timeless has spread in Europe over the past 10,000 years, possibly because it enhances diapause. We show that the mutant allele attenuates the photosensitivity of the circadian clock and causes decreased dimerization of the mutant TIMELESS protein isoform to CRYPTOCHROME, the circadian photoreceptor. This interaction results in a more stable TIMELESS product. These findings reveal a molecular link between diapause and circadian photoreception.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CIRCADIAN CLOCK; LATITUDINAL CLINES; CRYPTOCHROME; PHOTORECEPTOR; ENTRAINMENT; PACEMAKER; PROTEIN; |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Dec 2020 07:30 |
| Last Modified: | 07 Dec 2020 07:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32592 |
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