Rothhammer, T. and Bataille, F. and Spruss, T. and Eissner, G. and Bosserhoff, A-K (2007) Functional implication of BMP4 expression on angiogenesis in malignant melanoma. ONCOGENE, 26 (28). pp. 4158-4170. ISSN 0950-9232,
Full text not available from this repository. (Request a copy)Abstract
Analyses of malignant melanomas revealed a strong expression of bone morphogenic proteins (BMPs) and their autocrine effect in promoting cell invasion and migration. Here, we report a paracrine effect of BMPs on the vascular network. Both BMP2 and BMP4 induced tube formation as well as the migratory efficiency of microvascular endothelial cells. Melanoma cells with reduced BMP activity attracted less endothelial cells in invasion assays than control cells. Furthermore, reduction of BMPs in melanoma cells had a strong effect on vasculogenic mimicry. Tube formation on matrigel was analysed for melanoma cells as well as in co-cultures of endothelial and melanoma cells. Melanoma cells with reduced BMP activity were not capable of forming cordlike structures by themselves and additionally inhibited tube formation of the endothelial cells. Genes involved in angiogenesis turned out to be strongly downregulated in these cell clones. Tumors derived from cells with impaired BMP activity showed reduced tumor growth or large necrotic areas owing to lack of angiogenesis in in vivo analyses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE MORPHOGENETIC PROTEIN-2; VASCULOGENIC MIMICRY; TUMOR ANGIOGENESIS; ENDOTHELIAL-CELLS; EPITHELIAL-CELLS; GENE-THERAPY; ID PROTEINS; IN-VITRO; GROWTH; CANCER; malignant melanoma; endothelium; migration; invasion; angiogenesis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation Medicine > Lehrstuhl für Pathologie Chemistry and Pharmacy > Institute of Pharmacy |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Dec 2020 06:31 |
| Last Modified: | 04 Dec 2020 06:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32614 |
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