Glatz, Katharina and Pritt, Bobbi and Glatz, Dieter and Hartmann, Arndt and O'Brien, Michael J. and Blaszyk, Hagen (2007) A multinational, Internet-based assessment of observer variability in the diagnosis of serrated colorectal polyps. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 127 (6). pp. 938-945. ISSN 0002-9173,
Full text not available from this repository.Abstract
This Internet-based quiz (http://kathrin.unibas.ch/ polyp/) tested the diagnostic variability of 168 pathologists in the diagnosis of 20 colorectal polyps on 3 representative images, including hyperplastic polyps (HPs), traditional serrated adenomas (TSAs), sessile serrated adenomas (SSAs), and tubulovillous adenomas (TVAs). Interobserver variability for each of the 20 lesions was significant and was most pronounced for SSAs. Correct answers were independent of the participant's experience with TVAs, HPs, and TSAs. Participants with gastrointestinal subspecialty training and those who had read a reference article on serrated polyps gave a significantly higher percentage of correct answers for SSAs. The nomenclature used for serrated polyps was generally inconsistent. Our results suggest significant shortcomings in the routine H&E diagnosis of serrated colorectal polyps. A diagnostically unifying concept for lesions of the serrated neoplasia pathway, standardization of nomenclature, training of pathologists, and possibly development of ancillary techniques are of paramount importance for accurate patient management.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MICROSATELLITE-UNSTABLE ADENOCARCINOMAS; HYPERPLASTIC POLYPOSIS; MOLECULAR CHARACTERISTICS; KRAS MUTATIONS; ADENOMAS; BRAF; PATHWAYS; TELEPATHOLOGY; INSTABILITY; PHENOTYPE; serrated polyps; observer variability; colon; Internet |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Dec 2020 07:04 |
| Last Modified: | 04 Dec 2020 07:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32625 |
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