Matzdorf, Corina and Kurtz, A. and Hoecherl, Klaus (2007) COX-2 activity determines the level of renin expression but is dispensable for acute upregulation of renin expression in rat kidneys. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 292 (6). F1782-F1790. ISSN 1931-857X, 1522-1466
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The role of cyclooxygenase 2 (COX-2) in the control of renin is still a matter of debate, since studies with COX-2-deficient mice or with COX-2 inhibitors produced conflicting findings. Therefore, we studied the effect of the COX- 2 inhibitor SC-58236 on the regulation of the renin system in adult rat kidneys. Renocortical tissue levels and urinary excretion of PGE(2) were reduced to 65 and 40% of control values, respectively, after a single gavage of SC-58236 and did not further decrease on prolonged treatment. Plasma renin activity (PRA) and renin mRNA levels began to decrease after 3 days and reached a constant level of similar to 60% of control values after 5 days of treatment. Isoproterenol or left renal artery clipping for 2 days increased PRA and renin mRNA to similar levels in both vehicle- and SC-58236-treated rats after 2 days. Pretreatment with SC-58236 for 5 days, however, reduced the absolute increase in PRA and renin mRNA levels. Notably, the relative increases were not different between vehicle- and SC-58236-treated rats. Similar findings were observed for the stimulation of the renin system by angiotensin II inhibition and low salt intake. These findings indicate that COX-2 inhibition attenuates renin secretion and renin gene expression stimulated by a variety of parameters in proportion to the lowering of basal renin activity, while it does not interfere with the different stimulatory mechanism per se. As a consequence, it appears as if COX-2 activity relevantly determines the set point of the activity of the renin system in rat kidneys.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MACULA DENSA CYCLOOXYGENASE-2; RENOVASCULAR HYPERTENSION; BLOOD-PRESSURE; CYCLO-OXYGENASE-2 INHIBITION; SALT DEFICIENCY; RENAL-CORTEX; RELEASE; STIMULATION; SECRETION; PROSTAGLANDINS; SC-58236; renovascular hypertension; prostaglandins; cyclooxygenase; isoproterenol |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 615 Pharmacy |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz Chemistry and Pharmacy > Institute of Pharmacy |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Dec 2020 07:10 |
| Last Modified: | 04 Dec 2020 07:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32629 |
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