Holler, Ernst (2007) Risk assessment in haematopoietic stem cell transplantation: GvHD prevention and treatment. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 20 (2). pp. 281-294. ISSN 1521-6926, 1532-1924
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Graft-versus-host disease (GvHD) is the major cause of transplant-related mortality and morbidity. As it is closely related to the major therapeutic principle, graft-versus-leukaemia (GvL) effect, risk assessment has to balance both risks depending on the pre-transplant status. This is clearly demonstrated when comparing the two major strategies for prevention of GvHD. While the majority of approaches aiming at T-cell depletion show efficacy in reducing acute and chronic GvHD and transplant-related mortality, T-cell depletion also affects graft-versus-leukaemia effects and thus results in a higher relapse rate. Thus, standard prophylaxis relying on calcineurin inhibitors frequently results in at least equivalent or even superior long-term disease-free survival, and the risk of relapse has to be considered when selecting regimens for prevention of GvHD. In addition to this general dilemma, drug-specific side-effects and risks have to be considered when selecting regimens for GvHD prevention and treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; TERM-FOLLOW-UP; PROSPECTIVE RANDOMIZED-TRIAL; RECEPTOR MONOCLONAL-ANTIBODY; IDENTICAL SIBLING DONORS; CHRONIC MYELOID-LEUKEMIA; ACUTE GRAFT; MYCOPHENOLATE-MOFETIL; ALLOGENEIC TRANSPLANTATION; graft-versus-host disease; graft-versus-leukaemia; calcineurin inhibitors; corticosteroids |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Dec 2020 15:03 |
| Last Modified: | 02 Dec 2020 15:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32637 |
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