Raja, Chand and Graham, Peter and Rizvi, Syed M. Abbas and Song, Emma and Goldsmith, Helen and Thompson, John and Bosserhoff, Anja and Morgenstern, Alfred and Apostolidis, Christos and Kearsley, John and Reisfeld, Ralph and Allen, Barry J. (2007) Interim analysis of oxicity and response in phase 1 trial of systemic targeted alpha therapy for metastatic melanoma. CANCER BIOLOGY & THERAPY, 6 (6). pp. 846-852. ISSN 1538-4047, 1555-8576
Full text not available from this repository. (Request a copy)Abstract
Purpose: The aim is to assess toxicity and response of systemic alpha therapy for metastatic melanoma. Experimental design: This is an open-labelled Phase 1 dose escalation study to establish the effective dose of the a-immunoconjugate Bi-213-cDTPA-9.2.27 mAb (AIC). Tool: used to investigate the effects were physical examination; imaging of tumors pathology GFR; CT and changes in tumor marker. Responses were assessed using RECIST criteria. Results and discussion: Twenty-two patients with stage IV melanoma/in-transit metastasis were treated with activities of 55-947 MBq. Using RECIST criteria 50% showed stable disease and 14% showed partial response. One patient (6%) showed near complete response and was retreated because of an excellent response to the initial treatment, Another patient showed response in his tumor on mandible and reduction in lung lesions Overall 30% showed progressive disease. The tumor marker melanoma inhibitory activity protein (MIA) showed reductions over eight weeks in most of the patients. The disparity of dose with responders is discussed No toxicity was observed over the range of administered activities. Conclusion: Observation of responses without any toxicity indicates that targeted alpha therapy has the potential metastatic melanoma.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GLOMERULAR-FILTRATION RATE; MONOCLONAL-ANTIBODY; MALIGNANT-MELANOMA; ANTIGEN; CELLS; melanoma; metastasis; targeted alpha therapy; Bi-213; alpha radiation; monoclonal antibody 9.2.27; toxicity; response |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Dec 2020 15:08 |
| Last Modified: | 02 Dec 2020 15:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32639 |
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