Karioti, Anastasia and Skopeliti, Margarita and Tsitsilonis, Ourania and Heilmann, Joerg and Skaltsa, Helen (2007) Cytotoxicity and immunomodulating characteristics of labdane diterpenes from Marrubium cylleneum and Marrubium velutinum. PHYTOCHEMISTRY, 68 (11). pp. 1587-1594. ISSN 0031-9422,
Full text not available from this repository. (Request a copy)Abstract
From the aerial parts of Marrubium cylleneum, one labdane nor-diterpene has been isolated together with two labdane diterpenes, hitherto not known as natural products. The structures of the isolated compounds were established by means of NMR [H-1-H-1-COSY, H-1-C-13-HSQC, HMQC-TOCSY, HMBC, NOESY] and MS spectral analyses. Several diterpenoids from M. cylleneum and M. velutinum were tested for their cytotoxic effect against various cancer cell lines and their immunomodulating potential in human peripheral blood mononuclear cells in standard in vitro assays. Our results show a differential cytotoxicity of some compounds as well as their ability to improve selected lymphocyte functions. (c) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LEUKEMIC-CELL LINES; IN-VITRO; CANCER; DERIVATIVES; Marrubium cylleneum; Marrubium velutinum; lamiaceae; labdane diterpenes; Nor-diterpenes; cytotoxicity; lymphocyte activation |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Dec 2020 09:43 |
| Last Modified: | 09 Dec 2020 09:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32713 |
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