Heinemann, Frank and Budweiser, Stephan and Dobroschke, Jakob and Pfeifer, Michael (2007) Non-invasive positive pressure ventilation improves lung volumes in the obesity hypoventilation syndrome. RESPIRATORY MEDICINE, 101 (6). pp. 1229-1235. ISSN 0954-6111, 1532-3064
Full text not available from this repository. (Request a copy)Abstract
Background: Our objective was to study the Long-term effects of non-invasive positive pressure ventilation (NPPV) on lung function and gas exchange in patients with the obesity hypoventilation syndrome (OHS). Design: Prospective observational study in OHS patients performing NPPV over a period of 24 months. Results: We studied 35 clinically stable OHS patients with a mean body mass index (BMI) 45.9 +/- 8.8 kg/m(2) and daytime PaCO2 at room air of 6.92 +/- 0.48 kPa at baseline. Nocturnal NPPV was initiated with pressure-cycted devices on IPAP 24 +/- 3cm H2O, EPAP 6 +/- 2 cm H2O and respiratory frequency of 18.8 +/- 3.7/min. After 12 and 24 months of NPPV hypercapnia was persistently normalized and hypoxemia was markedly improved white no changes in calculated alveolar-arterial oxygen difference occurred. Augmented ventilation was followed by a significant reduction in hemoglobin and hematocrit (P < 0.001 each). Daily duration of ventilator use significantly correlated with the decrease in PaCO2 after 12 months (r = 0.37; P < 0.05) and 24 months (r = 0.47; P < 0.05). Vital capacity (VC) and expiratory reserve volume (ERV) significantly increased after 12 and 24 months NPPV compared to the baseline values, though BMI was only slightly reduced. The 2-year survival rate was 91% with three patients (9%) discontinuing NPPV during the study period. Conclusion: Long-term domiciliary NPPV normalizes hypercapnia and markedly improves hypoxemia as well as polycythemia in OHS patients. In addition, NPPV Leads to a significant reduction in restrictive ventilatory disturbance, predominantly by increasing ERV.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXPIRATORY FLOW LIMITATION; MECHANICAL VENTILATION; RESPIRATORY-FAILURE; MORBID-OBESITY; DISTURBANCES; GASTROPLASTY; TERM; chronic ventilatory failure; non-invasive positive pressure ventilation; obesity hypoventilation syndrome; pulmonary function test; restrictive ventilatory disorder |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Dec 2020 09:44 |
| Last Modified: | 11 Jan 2021 09:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32718 |
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