Krueger, Bernd and Boeger, Carsten A. and Obed, Aiman and Farkas, Stefan and Hoffmann, Ute and Banas, Bernhard and Fischereder, Michael and Kraemer, Bernhard K. (2007) RANTES/CCL5 polymorphisms as a risk factor for recurrent acute rejection. CLINICAL TRANSPLANTATION, 21 (3). pp. 385-390. ISSN 0902-0063,
Full text not available from this repository. (Request a copy)Abstract
Background: The chemokine system plays an important role in the pathogenesis of acute rejection or atherosclerosis. Three polymorphisms in the promoter region of the chemokine RANTES (-403G/A, -28G/C, In1.1T/C) are associated with a different expression of this chemokine as well as the occurrence of cardiovascular disease. Therefore, we investigated the impact of these three polymorphisms on the outcome after renal transplantation. Methods: In 261 patients receiving their first kidney transplant, we genotyped the RANTES promoter polymorphisms (-403G/A, -28G/C, In1.1T/C) by real-time PCR. Results: For the RANTES -403G/A and for the intronic polymorphism In1.1T/C, we found a significantly higher rate of recurrent acute rejection episodes (-403G/A: 11.1 vs. 31.0%, In1.1T/C: 11.8 vs. 33.0%). For the overall rate of acute rejection, we observed no significant differences according to the RANTES promoter polymorphisms. The other tested variables (DGF, graft survival, renal function) were not associated with one of the three polymorphisms. Conclusion: Our data indicate a relevant role of RANTES in kidney transplantation, particularly for the occurrence of recurrent acute rejection. To clarify the role of the analysed polymorphisms for long-term survival, especially for the occurrence of cardiovascular events, larger studies in the future are needed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC ALLOGRAFT NEPHROPATHY; RENAL-TRANSPLANTATION; ATOPIC-DERMATITIS; GRAFT FUNCTION; PROMOTER; SURVIVAL; DISEASE; CHEMOKINES; IMPACT; MCP-1; kidney transplantation; rantes; renal function |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Dec 2020 11:17 |
| Last Modified: | 10 Dec 2020 11:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32794 |
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