Rudolph, C. and Sigruener, A. and Hartmann, A. and Orso, E. and Bals-Pratsch, M. and Gronwald, W. and Seifert, B. and Kalbitzer, H. R. and Verdorfer, I. and Luetjens, C. M. and Ortmann, O. and Bornstein, S. R. and Schmitz, G. (2007) ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis. HORMONE AND METABOLIC RESEARCH, 39 (5). pp. 322-335. ISSN 0018-5043,
Full text not available from this repository. (Request a copy)Abstract
The screening for additional human YjeF_N domain containing proteins beside the apolipoprotein A-I interacting protein (Al-BP), identified two other genes designated hYjeF_N2-15q23 (formerly human homologue of yeast edc3) and hYjeF_N3-19p13.11 comprising the human YjeF_N family. AI-BP is ubiquitously expressed, with a predominance of these tissues where the homologues were found to be restricted including brain, mammary gland, testes and ovaries. Immunohistochemistry of human testes and ovaries showed an expression of hYjeF-N3-19p13.11 only in Leydig cells and theca cells, respectively, indicating a role in steroid hormone metabolism. Interestingly, the protein was also strongly expressed in Leydig cell tumors and in thecofibromas. The identification of hYjeF_N215q23 in theca cells and granulosa cells in ovaries, in human spermatids of meiotic division part II and the apical membrane of Sertoli cells in testes suggest similar functions in oogenesis and sperm maturation which is strengthened by the identification of the spermatogenesis regulator HMGA1 as a conserved transcription factor. However, in contrast to AI-BP, both homologous proteins are unable to bind apoA-I. These results relate the human YjeF_N domain containing protein family to cholesterol processing and steroid hormone metabolism in spermiogenesis and oogenesis, and AI-BP may link this function to the HDL pathway.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OCT-1 TRANSCRIPTION FACTOR; HIGH-DENSITY-LIPOPROTEINS; MESSENGER-RNA; CHOLESTEROL EFFLUX; OVARIAN GRANULOSA; SPERM DEVELOPMENT; LIPID-METABOLISM; MALE-FERTILITY; SERTOLI-CELLS; TESTIS; ABCA1; ApoA-I; hYjeF_N1-1q21; hedc3; Leydig cells |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Lehrstuhl für Pathologie Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Dec 2020 11:27 |
| Last Modified: | 10 Dec 2020 11:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32816 |
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