Delaney, Tetyana L. and Zimin, Denys and Rahm, Michael and Weiss, Dieter and Wolfbeis, Otto S. and Mirsky, Vladimir M. (2007) Capacitive detection in ultrathin chemosensors prepared by molecularly imprinted grafting photopolymerization. ANALYTICAL CHEMISTRY, 79 (8). pp. 3220-3225. ISSN 0003-2700
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The usual applications of capacitive detection in chemo- and biosensors are based on changes in effective thickness of insulating layers due to adsorption of analyte onto receptors. Ultrathin chemosensors based on molecularly imprinted polymerization enable a realization of another capacitive approach that exploits changes in electrical capacitance due to modification of the dielectric constant of the polymer. Such chemosensors were prepared by photografted molecularly imprinted polymerization on the surface of gold electrodes. An adsorbed layer of hydrophobic photoinitiator (benzophenone) provided grafted polymerization on the surface of the alkanethiol-modified gold electrode. The chemosensors were characterized by cyclic voltammetry, impedance spectroscopy, and scanning electron and atomic force microscopy. Binding of analyte was detected by measurements of electrical capacitance. The results indicate a decrease of the dielectric constant of the polymer layer due to analyte binding up to 20%.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHARMACEUTICAL ANALYSIS; PROTEIN IMMOBILIZATION; BIOMIMETIC SENSORS; GOLD ELECTRODES; POLYMERS; MONOLAYERS; ADSORPTION |
| Subjects: | 500 Science > 530 Physics 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Physics > Institute of Experimental and Applied Physics > Chair Professor Weiss > Group Dieter Weiss Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Aug 2023 07:06 |
| Last Modified: | 10 Aug 2023 07:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32879 |
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