Torner, Luz and Plotsky, Paul M. and Neumann, Inga D. and de Jong, Trynke R. (2017) Forced swimming-induced oxytocin release into blood and brain: Effects of adrenalectomy and corticosterone treatment. PSYCHONEUROENDOCRINOLOGY, 77. pp. 165-174. ISSN 0306-4530,
Full text not available from this repository. (Request a copy)Abstract
The oxytocin (OXT) system is functionally linked to the HPA axis in a reciprocal and complex manner. Certain stressors are known to cause the simultaneous release of OXT and adrenocorticotrophic hormone (ACTH) followed by corticosterone (CORT). Furthermore, brain OXT attenuates ACTH and CORT responses. Although there are some indications of CORT influencing OXT neurotransmission, specific effects of CORT on neurohypophyseal or intra-hypothalamic release of OXT have not been studied in detail. In the present set of experiments, adult male rats were adrenalectomized (ADX) or sham-operated and fitted with a jugular vein catheter and/or microdialysis probe targeting the hypothalamic paraventricular nucleus (PVN). Blood samples and dialysates were collected before and after forced swimming (FS) and analyzed for CORT, ACTH and AVP concentrations (in plasma) and OXT concentrations (in plasma and dialysates). Experimental treatments included acute infusion of CORT (70 or 175 mu g/kg i.v.) 5 min prior to FS, or subcutaneous placement of 40% CORT pellets resulting in stable CORT levels in the normal basal range. Although ADX did not alter basal OXT concentrations either in plasma or in microdialysates from the PVN, it did cause an exaggerated peripheral secretion of OXT and a blunted intra-PVN release of OXT in response to FS. CORT pellets did not influence either of these ADX-induced effects, while acute infusion of 175 mu g/kg CORT rescued the stress-induced rise in OXT release within the PVN and modestly increased peripheral OXT secretion. In conclusion, these results indicate that CORT regulates both peripheral and intracerebral OXT release, but in an independent manner. Whereas the peripheral secretion of OXT occurs simultaneously to HPA axis activation in response to FS and is modestly influenced by CORT, HPA axis activation and circulating CORT strongly contribute to the stress-induced stimulation of OXT release within the PVN. (C) 2016 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PARVOCELLULAR NEUROSECRETORY NEURONS; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; VASOPRESSIN NEURONS; OSMOTIC STIMULATION; MAGNOCELLULAR-NEURONS; PERIPHERAL RELEASE; RECEPTOR-BINDING; MESSENGER-RNA; RAT-BRAIN; STRESS; Oxytocin; Corticosterone; ACTH; Stress; HPA axis; Adrenalectomy |
| Subjects: | 500 Science > 580 Botanical sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 19 Feb 2019 10:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/329 |
Actions (login required)
 |
View Item |
