Maaijwee, Kristel J. M. and van Meurs, Jan C. and Kirchhof, Bernd and Mooij, Cornelia M. and Fischer, Jurgen H. and Mackiewicz, Jerzy and Kobuch, Karin and Joussen, Antonia M. (2007) Histological evidence for revascularisation of an autologous retinal pigment epithelium-choroid graft in the pig. BRITISH JOURNAL OF OPHTHALMOLOGY, 91 (4). pp. 546-550. ISSN 0007-1161,
Full text not available from this repository. (Request a copy)Abstract
Background: Translocation of a free autologous graft consisting of retinal pigment epithelium (RPE), Bruch's membrane, choriocapillaris and choroid in patients with exudative age-related macular degeneration is currently being evaluated in clinical practice. Angiographic studies in these patients suggest that their grafts become revascularised. Aim: To investigate the histological evidence of revascularisation of the graft in a porcine model. Methods: In 11 pigs (11 eyes), an RPE-choroid graft was translocated from the mid-periphery to an intact or an intentionally damaged RPE and Bruch's membrane at the recipient site. The eyes were enucleated 1 week or 3 months after surgery. Tissue sections were evaluated using immunohistochemistry. Results: Bridging vessels between recipient layer and graft were identified from 1 week to 3 months after surgery. This reconnection occurred regardless of whether the Bruch's membrane of the recipient site was left intact or intentionally damaged at the time of transplantation. The vasculature of the graft appeared open and perfused. Vessels with transcapillary pillars and conglomerates of small new vessels were present in the graft. Conclusions: This study showed histological evidence for revascularisation by angiogenesis of a free autologous RPE-choroid graft.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUBFOVEAL NEOVASCULAR MEMBRANES; AGE-RELATED MACULOPATHY; MACULAR DEGENERATION; MINIATURE PIG; FOLLOW-UP; TRANSLOCATION; TRANSPLANTATION; RETINOTOMY; MANAGEMENT; SURGERY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Dec 2020 06:56 |
| Last Modified: | 16 Dec 2020 06:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32926 |
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