Babilas, Philipp and Shafirstein, Gal and Baier, Juergen and Schacht, Vivien and Szeimies, Rolf-Markus and Landthaler, Michael and Baeumler, Wolfgang and Abels, Christoph (2007) Photothermolysis of blood vessels using indocyanine green and pulsed diode laser irradiation in the dorsal skinfold chamber model. LASERS IN SURGERY AND MEDICINE, 39 (4). pp. 341-352. ISSN 0196-8092, 1096-9101
Full text not available from this repository. (Request a copy)Abstract
Background and Objective: For the treatment of vascular lesions, the use of laser light absorbed by the endogenous chromophore hemoglobin may still be improved. Materials and Methods: Laser treatment (lambda(em)=805 nm; fluence rate: 106 kW/cm(2); fluence: 3.2 J/cm(2) (3 milliseconds)), of blood vessels directly after i.v. application of indocyanine green (ICG) (ICG-concentration: 0, 2, or 4 mg/kg body weight (b.w.)) (n = 14,117) was investigated in the skinfold chamber model. Vessel diameters (1-351 mu m) were measured using intravital fluorescence microscopy up to 24 hours following irradiation. Histology was taken 1 or 24 hours after irradiation. Results were compared to a mathematical model based on the finite element method. Results: The reduction of blood vessel perfusion was proportional to ICG-concentration and pulse duration; only a 30 milliseconds pulse duration (2 or 4 mg/kg b.w. ICG-concentration) induced a loss of perfusion even of blood vessels with a diameter <30 mu m. Histology revealed photocoagulation of blood vessels up to 24 hours. Results were in agreement with mathematical calculations. Conclusion: ICG-mediated laser irradiation induces irreversible photocoagulation of blood vessels of all diameters in this model. Lasers Surg. Med. 39:341-352, 2007. (C) 2007 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PORT-WINE STAINS; TUNABLE DYE-LASER; RED-CELL MEMBRANE; IN-VIVO; SELECTIVE PHOTOTHERMOLYSIS; CHOROIDAL NEOVASCULARIZATION; PHOTODYNAMIC THERAPY; THERMAL-DAMAGE; FLAP MODEL; TISSUE; hamster; intravital microscopy; port-wine stain; vascular |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Dec 2020 07:24 |
| Last Modified: | 21 Dec 2020 07:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/32981 |
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