Bosch, Oliver J. and Muesch, Werner and Bredewold, Remco and Slattery, David A. and Neumann, Inga D. (2007) Prenatal stress increases HPA axis activity and impairs maternal care in lactating female offspring: Implications for postpartum mood disorder. PSYCHONEUROENDOCRINOLOGY, 32 (3). pp. 267-278. ISSN 0306-4530
Full text not available from this repository. (Request a copy)Abstract
Early life stress is believed to constitute a risk factor for the development of mood disorders later in life. In the present study, we hypothesized that prenatal stress (PS) exerts long-lasting effects in female rat offspring, resulting in impaired adaptations to stress during lactation and, as such, may be a contributory factor to postpartum mood disorders. PS increased anxiety in adult virgin females compared with controls. During lactation, PS dams nursed significantly less and spent less time with pups compared with controls, whereas dams did not differ in pup retrieval or maternal. aggression. HPA axis reactivity was elevated in response to a mild stressor in PS dams compared to their controls, but not in virgins, with the delta corticosterone response returning to the higher level, seen in virgins. Moreover, corticotropin-releasing hormone (CRH) mRNA expression within the parvocellular region of the paraventricular nucleus (PVN) was increased in both virgins and dams exposed to PS compared with the relative controls, white the attenuation in expression in lactating controls was abolished following PS. In addition, arginine vasopressin (AVP) mRNA was increased in the parvocellular, but not magnocellular part of the PVN, in both PS-exposed virgins and lactating dams compared with their relative controls; although expression was also higher in controls during lactation compared with virgins. Thus, the present study demonstrates that exposure to PS results in long-lasting behavioural and neuroendocrine alterations in the female offspring, which are manifested during the lactation period. Furthermore, it implicates PS as a potential risk factor for the development of postpartum mood disorders, and that alterations in the HPA axis reactivity, at least partially, are involved. (c) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENAL AXIS; RECEPTOR ANTISENSE OLIGODEOXYNUCLEOTIDE; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MESSENGER-RNA EXPRESSION; ANXIETY-RELATED BEHAVIOR; ADULT-RATS; HORMONAL RESPONSES; STRIA TERMINALIS; RESTRAINT STRESS; arched back nursing; corticotropin-releasing hormone; elevated plus-maze; stress response |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Zoologie/Evolutionsbiologie (Prof. Dr. Jürgen Heinze) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 29 Oct 2020 07:52 |
| Last Modified: | 29 Oct 2020 07:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33006 |
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