Poeling, Jochen and Leptien, Alexander and Klaus, Stephan and Rees, Wolfgang and Kraatz, Ernst and Wiebe, Karsten and Bahlmann, Ludger (2007) Analysis of the myocardial metabolism by microdialysis during open beating heart surgery. SCANDINAVIAN CARDIOVASCULAR JOURNAL, 41 (2). pp. 114-119. ISSN 1401-7431,
Full text not available from this repository. (Request a copy)Abstract
Objectives. Microdialysis allows the in vivo biochemical analysis of interstitial fluids. Our aim was to reveal in vivo reliable data of the myocardium during open beating heart surgery. Design. In ten patients undergoing routine beating coronary artery bypass grafting a microdialysis catheter was inserted into the left ventricle. Measurements were performed up to 45 min after anastomosis. Data were retrospectively compared with standard on-pump procedures. Results. The myocardial lactate remained stable during anastomosis, followed by a significant decrease of lactate after revascularisation. Myocardial glucose levels showed a slight decrease, followed by a significant increase after revascularisation. Myocardial purines showed a slight increase during anastomosis, followed by a sharp decrease during reperfusion period. Conclusions. In contrast to on-pump procedures myocardial lactate and purines showed less increasing trend during the ischemic period, while myocardial glucose remained stable as a sign of preserved tissue blood flow. Myocardial microdialysis showed different values compared to the elective on-pump CABG and previous animal studies. This technique allows bedside monitoring of biochemical changes, suggesting its possible role as a clinical monitoring tool.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORONARY-BYPASS SURGERY; OFF-PUMP; ON-PUMP; CARDIOPULMONARY BYPASS; REPERFUSION; ISCHEMIA; HYPOXIA; INJURY; cardiovascular diseases; microcirculation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Dec 2020 09:56 |
| Last Modified: | 21 Dec 2020 09:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33012 |
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