Langguth, Berthold and Bauer, Elena and Feix, Sebastian and Landgrebe, Michael and Binder, Harald and Sand, Philipp and Hajak, Goeran and Eichhammer, Peter (2007) Modulation of human motor cortex excitability by the cholinesterase inhibitor rivastigmine. NEUROSCIENCE LETTERS, 415 (1). pp. 40-44. ISSN 0304-3940,
Full text not available from this repository. (Request a copy)Abstract
Acetylcholine exerts strong neuromodulating action at cortical and subcortical neurons and networks. Alterations of cortical excitability, induced by acute and repeated administration of the acetylcholinesterase inhibitor rivastigmine were investigated with transcranial magnetic stimulation in healthy volunteers. It was found that rivastigmine had an overall significant effect on the stimulus-response curve with mean values suggesting an enhancement 1.5 and 3 h after a single loading dose of 3 mg rivastigmine and a reduction after 7 days of daily administration of 3 mg rivastigmine. Motor threshold, intracortical inhibition, intracortical facilitation, cortical silent period, M-wave, F-wave and peripheral silent period remained unaffected either by acute or repeated administration of rivastigmine. Our results demonstrate that effects of acetylcholine on motor cortex excitability in healthy subjects are reflected by alterations of the stimulus-response curve. The differential effect between acute and chronic administration of rivastigmine may reflect dynamic properties of different receptor subtypes. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRANIAL MAGNETIC STIMULATION; CORTICAL EXCITABILITY; ALZHEIMERS-DISEASE; IN-VITRO; CIRCUITS; NEURONS; cholinesterase inhibitor; rivastigmine; human motor cortex; excitability; transcranial magnetic stimulation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Dec 2020 10:26 |
| Last Modified: | 21 Dec 2020 10:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33033 |
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