Douglas, A. J. and Meddle, S. L. and Kroemer, S. and Bosch, O. J. and Neumann, I. D. (2007) Social stress induces hypothalamo-pituitary-adrenal axis responses in lactating rats bred for high trait anxiety. EUROPEAN JOURNAL OF NEUROSCIENCE, 25 (5). pp. 1599-1603. ISSN 0953-816X,
Full text not available from this repository. (Request a copy)Abstract
Hypothalamo-pituitary-adrenal axis responses to various stressors are typically attenuated during lactation, including in rats selectively bred for high or low anxiety. As high-anxiety dams are more aggressive towards intruders than low-anxiety dams during maternal defence, we investigated their hypothalamo-pituitary-adrenal axis responses to this social stress. Maternal defence induced elevated stress responses in high-anxiety dams only; nerve-growth-factor-induced gene B mRNA expression in the parvocellular paraventricular nucleus and adrenocorticotropin hormone secretory responses were substantially enhanced after maternal defence. In contrast, secretory responses to a non-social stress (elevated platform) were not different between high- and low-anxiety dams. Thus, responsiveness of the stress axis in lactation is dependent upon the innate level of anxiety of the dam and, as a consequence, her reactiveness to social threat.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORTICOTROPIN-RELEASING HORMONE; MESSENGER-RNA EXPRESSION; NEUROENDOCRINE RESPONSES; BEHAVIORAL PARAMETERS; NEURONAL ACTIVATION; BRAIN OXYTOCIN; C-FOS; PREGNANCY; HYPORESPONSIVENESS; VASOPRESSIN; ACTH; amygdala; elevated platform; maternal defence; NGFIB; paraventricular nucleus |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Dec 2020 13:18 |
| Last Modified: | 21 Dec 2020 13:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33072 |
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