Herrmann, Wolfgang Artur and Muecke, Manuela and Koller, Michael and Gabel, Veit Peter and Lohmann, Chris Patrick (2007) Keratocyte density in the retroablation area after LASEK for the correction of myopia. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 245 (3). pp. 426-430. ISSN 0721-832X,
Full text not available from this repository. (Request a copy)Abstract
Purpose: During excimer laser photoablation keratocyte cell death is induced in the retroablation area. Afterwards this area is repopulated by keratocyte mitosis and migration from the adjacent stroma. The aim of this study was to investigate keratocyte density in the retroablation area and in the posterior stroma during the first year after LASEK for the correction of myopia. Methods: In a prospective study LASEK surgery was performed in 17 eyes of 10 consecutive patients for the correction of myopia (-2.25 D to -9.0 D, mean -5.0 D). Confocal microscopy (Nidek Confoscan 2) was performed before surgery and 1 month, 3 months, 6 months and 12 months after LASEK. Keratocyte density was assessed in the anterior retroablation area at depths of 5 mu m and 25 mu m and in the posterior stroma at distances of 5 mu m and 100 mu m from the corneal endothelium and compared with the corresponding area before surgery. Results: Keratocyte density was statistically significant reduced in the retroablation area at all timepoints after LASEK. At a depth of 5 mu m, cell densities were decreased by 64%, 47%, 43%, and 28% at 1 month, 3 months, 6 months and 12 months after LASEK compared with preoperative values. At a depth of 25 mu m, cell densities were decreased by 51%, 32%, 28%, and 18% at 1 month, 3 months, 6 months and 12 months after LASEK compared with preoperative values. In the posterior stroma no significant change in keratocyte density was observed at any time after LASEK. Conclusions: Keratocyte density in the anterior retroablation area recovers during the first year after LASEK for the correction of myopia, but does not go back to preoperative values.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHOTOREFRACTIVE KERATECTOMY; CONFOCAL MICROSCOPY; LONG-TERM; IN-VIVO; APOPTOSIS; CORNEA; STROMA; PROLIFERATION; TISSUE; LASIK; LASEK; keratocyte density; confocal microscopy; refractive surgery; corneal wound healing |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Dec 2020 09:34 |
| Last Modified: | 21 Dec 2020 09:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33098 |
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