Stadlmann, Sylvia and Gueth, Uwe and Wight, Edward and Kunz-Schughart, Leoni A. and Hartmann, Arndt and Singer, Gad (2007) Expression of peroxisome proliferator activated receptor gamma and cyclo-oxygenase 2 in primary and recurrent ovarian carcinoma. JOURNAL OF CLINICAL PATHOLOGY, 60 (3). pp. 307-310. ISSN 0021-9746, 1472-4146
Full text not available from this repository. (Request a copy)Abstract
Aim: Peroxisome proliferator-activated receptor gamma (PPAR gamma) has emerged as a potential therapeutic target in several types of cancer. In ovarian carcinomas, limited and conflicting data on PPARc protein expression have been reported. Methods: The immunoexpression of PPAR gamma and its putative target cyclo-oxygenase 2 (COX2) was investigated in tumour tissues from 80 patients with primary and corresponding recurrent ovarian serous carcinomas after conventional platinum-based chemotherapy. Results: PPARc expression was observed in 29% of primary and recurrent carcinomas. In the recurrent tumours, PPARc expression inversely correlated with COX2 overexpression in both chemosensitive (p = 0.02) and chemoresistant (p = 0.04) carcinomas. Conclusions: The data indicate that PPARc may represent a potential target for second-line treatment in ovarian cancers.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PPAR-GAMMA; BREAST-CANCER; CHEMOTHERAPY RESISTANCE; GROWTH-INHIBITION; SEROUS CARCINOMA; PHASE-II; TROGLITAZONE; AGONISTS; CELLS; COX-2; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Dec 2020 06:55 |
| Last Modified: | 22 Dec 2020 06:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33110 |
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