Delayed humoral immunity in a patient with severe tick-borne encephalitis after complete active vaccination

Kleiter, I. and Jilg, W. and Bogdahn, U. and Steinbrecher, A. (2007) Delayed humoral immunity in a patient with severe tick-borne encephalitis after complete active vaccination. INFECTION, 35 (1). pp. 26-29. ISSN 0300-8126,

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Abstract

Tick-borne encephalitis virus (TBEV) is a common cause of viral encephalitis in parts of Central and Eastern Europe. Active immunization results in a high rate of seroconversion and is the most effective measure of decreasing the incidence of tick-borne encephalitis (TBE). Currently, booster vaccinations are recommended every 3 years after completion of primary immunization. However, titers of neutralizing antibodies decline with time after vaccination and with age and thus may be insufficient to protect from disease in the elderly. We report on a 54-year-old patient who had received his last booster vaccination 3 years before developing a severe TBE with delayed induction and longterm persistence of anti-TBEV-IgM-antibodies.

Item Type: Article
Uncontrolled Keywords: CHAIN-REACTION ASSAY; VIRUS; PERSISTENCE; DIAGNOSIS; VACCINES;
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Medicine > Lehrstuhl für Neurologie
Depositing User: Dr. Gernot Deinzer
Date Deposited: 22 Dec 2020 12:13
Last Modified: 22 Dec 2020 12:13
URI: https://pred.uni-regensburg.de/id/eprint/33231

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