Warren, Alessandra and Bertolino, Patrick and Benseler, Volker and Fraser, Robin and McCaughan, Geoffrey W. and Le Couteur, David G. (2007) Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. JOURNAL OF HEPATOLOGY, 46 (2). pp. 239-246. ISSN 0168-8278,
Full text not available from this repository. (Request a copy)Abstract
Background/Aims: The liver sinusoidal endothelial cell (LSEC) is increasingly recognized as having an important role in hepatic immunity. However, the responses of LSECs and the hepatic sinusoid in immune-mediated hepatitis are poorly described. Methods: We studied a transgenic mouse model of acute immune-mediated hepatitis: Met-K-b mice injected with T cells from Des-TCR mice. Results: Hepatitis was characterized by lymphocyte infiltrates causing severe but transient liver damage. There were marked changes in the ultrastructure of the LSEC five days after injection of the T cells that coincided with the peak of the hepatitis. The porosity of fenestrations in the LSEC decreased and the endothelium became thickened. LSECs appeared to be markedly activated. These changes were associated with narrowing of the space of Disse, loss of hepatocellular microvilli and deposition of basal lamina. Lymphocytes were seen passing through fenestrations. Loss of fenestration in the LSEC prevented hepatitis induced by a second injection of lymphocytes on day 5. Conclusions: Structural changes in the LSEC occur during the peak of a mouse model of immune-mediated hepatitis. These changes were associated with attenuation of subsequent liver damage, suggesting that they may influence immunological responses mediated by LSECs or the passage of lymphocytes through LSEC fenestrations. (c) 2006 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CD8(+) T-CELLS; ENDOTHELIAL-CELL; RECEPTOR STIMULATION; LIVER SIEVE; RAT-LIVER; ACTIVATION; TOLERANCE; CIRRHOSIS; MICE; PSEUDOCAPILLARIZATION; hepatitis; hepatocyte; liver sinusoidal endothelial cell; fenestration; mice |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Dec 2020 12:42 |
| Last Modified: | 22 Dec 2020 12:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33245 |
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