Dilger, Karin and Schaeffeler, Elke and Lukas, Milan and Strauch, Ulrike and Herfarth, Hans and Mueller, Ralph and Schwab, Matthias (2007) Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohn's disease during 1 year of treatment with azathioprine or mesalazine. THERAPEUTIC DRUG MONITORING, 29 (1). pp. 1-5. ISSN 0163-4356, 1536-3694
Full text not available from this repository. (Request a copy)Abstract
Thiopurine methyltransferase (TPMT) activity determines biotransformation of azathioprine and, thereby, drug efficacy and safety, Evaluation of a possible long-term effect of mesalazine or azathioprine on TPMT activity is of particular clinical importance because both drugs can to be given for several years in inflammatory bowel disease. Monitoring of TPMT activity and three thiopurine metabolites was performed prospectively during a 1 year postoperative period in 21 patients with Crohn's disease randomly assigned to azathioprine (2.0-2.5 mg/kg per day) or mesalazine (4 g/day). TPMT activity did not change significantly within each treatment group during 52 weeks. At any study visit, TPMT activity was not different between 13 patients on azathioprine and eight patients on mesalazine. Concentrations of 6-thioguanine nucleotides (6-TGN, active moiety of azathioprine) and 6-methyl-mercaptopurine ribonucleotides (6-MMPR) did not alter significantly during the observation period, except for a slight decrease in 6-TGN levels when comparing the first with the last visit. In this first report of serial monitoring of 6-methyl-thioguanine nucleotides (6-MTGN) in patients with inflammatory bowel disease taking azathioprine, high levels of 6-TGN were correlated with high levels of 6-MTGN, with the mean 6-TGN: 6-MTGN ratio being 2.4. In a well-standardized clinical setting of inflammatory bowel disease, neither mesalazine nor azathioprine significantly affected TPMT activity during a whole year of treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; ACUTE LYMPHOBLASTIC-LEUKEMIA; S-METHYLTRANSFERASE; 6-MERCAPTOPURINE THERAPY; TRANSPLANT RECIPIENT; HUMAN ERYTHROCYTES; IN-VIVO; 6-THIOGUANINE; MESALAMINE; MYELOSUPPRESSION; azathioprine; Crohn's disease; mesalazine; thiopurine metabolites; thiopurine methyltransferase |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Dec 2020 06:26 |
| Last Modified: | 23 Dec 2020 06:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33275 |
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