Hungerhuber, Edwin and Stepp, Herbert and Kriegmair, Martin and Stief, Christian and Hofstetter, Alfons and Hartmann, Arndt and Knuechel, Ruth and Karl, Alexander and Tritschler, Stefan and Zaak, Dirk (2007) Seven years' experience with 5-aminolevulinic acid in detection of transitional cell carcinoma of the bladder. UROLOGY, 69 (2). pp. 260-264. ISSN 0090-4295, 1527-9995
Full text not available from this repository. (Request a copy)Abstract
OBJECTIVES Photodynamic diagnosis (PDD) using 5-aminolevulinic acid has proved to be a procedure with an outstanding sensitivity for the detection of transitional cell carcinoma of the bladder, in particular in the detection of flat urothelial lesions. We report on our clinical results with 875 patients (1713 PDD procedures) between March 1995 and March 2002. METHODS A total of 1713 PDD procedures were done in 875 patients. Fluorescence imaging was performed 2 to 3 hours after instillation of 50 mL of a 3% solution of 5-aminolevulinic acid into the bladder by an incoherent light source. In total, specimens from 4630 lesions (2.7 tesions/PDD) were taken. RESULTS In 34.8% of all biopsies, the histologic finding was malignant; 23.7% of these biopsies had been taken only because of positive fluorescence. In 28.5.% of the positive biopsies, flat lesions had been identified. Also, 43.4% of carcinoma in situ and 30.7% of dysplasia II degrees were detected only by positive fluorescence. Of all tumor lesions, 92.0% were detected by PDD compared with 76.3% detected by white tight endoscopy. CONCLUSIONS PDD has proved to be an effective detection device for superficial bladder cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INDUCED FLUORESCENCE DIAGNOSIS; FREQUENT GENETIC ALTERATIONS; TRANSURETHRAL RESECTION; UROTHELIAL HYPERPLASIAS; URINARY-BLADDER; IN-SITU; CANCER; TUMORS; RECURRENCE; DYSPLASIA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Dec 2020 07:02 |
| Last Modified: | 23 Dec 2020 07:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33279 |
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