Barth, Teresa and Zeman, Florian and Helbig, Horst and Oberacher-Velten, Isabel (2016) Etiology and treatment of choroidal neovascularization in pediatric patients. EUROPEAN JOURNAL OF OPHTHALMOLOGY, 26 (5). pp. 388-393. ISSN 1120-6721, 1724-6016
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Purpose: To assess the etiology, clinical features, and outcome of choroidal neovascularization (CNV) in children. Methods: We retrospectively assessed 10 eyes of 8 patients younger than 18 years diagnosed with CNV. The main clinical parameters included predisposing ocular pathologies, best-corrected visual acuity before and after treatment, characteristics of CNV, and treatment modalities. Results: Two boys and 6 girls with CNV and a mean age of 13.9 years (SD 1.9, range 11-16 years) were included. Two patients developed bilateral CNV within the follow-up time. The development of CNV was secondary to the following pathologies: choroidal osteoma (n = 3), pathologic myopia (n = 1), punctate inner choroidopathy (n = 1), hereditary macular dystrophy (n = 2), and angioid streaks (n = 1). Idiopathic CNV was diagnosed in 2 children without any obvious associated ocular pathology. In 9 eyes, CNV was treated by intravitreal anti-vascular endothelial growth factor (VEGF) administration (n = 6), photodynamic therapy (n = 1), or combination therapy (n = 3). One eye remained untreated because of advanced disease. Conclusions: Pediatric CNV is a rare but sight-threatening retinal disease. So far, no standard treatment has been validated. Since the establishment of intravitreal anti-VEGF therapy, laser coagulation and photodynamic therapy have lost their significance as therapy for CNV.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHOTODYNAMIC THERAPY; INTRAVITREAL BEVACIZUMAB; CHILDREN; VERTEPORFIN; ADOLESCENTS; AVASTIN; EYES; AGE; Anti-vascular endothelial growth factor; Choroidal neovascularization; Intravitreal injections; Pediatric retinal disease; Visual impairment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Mar 2019 08:57 |
| Last Modified: | 25 Mar 2019 08:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3329 |
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