Tessmar, Joerg K. and Goepferich, Achim M. (2007) Customized PEG-derived copolymers for tissue-engineering applications. MACROMOLECULAR BIOSCIENCE, 7 (1). pp. 23-39. ISSN 1616-5187,
Full text not available from this repository. (Request a copy)Abstract
PEG-containing copolymers play a prominent role as biomaterials for different applications ranging from drug delivery to tissue engineering. These custom-designed materials offer enormous possibilities to change the overall characteristics of biomaterials by improving their biocompatibility and solubility, as well as their ability to crystallize in polymer blends and to resist protein adsorption. This article demonstrates various principles of PEG-based material design that are applied to fine tune the properties of biomaterials for different tissue engineering applications. More specifically, strategies are described to develop PEG copolymers with various block compositions and specific bulk properties, including low melting points and improved surface hydrophilicity. Highly hydrated polymer gel networks for promoting cellular growth or suppressing protein adsorption and cell adhesion are introduced. By incorporating selectively cleavable cross-links, these hydrophilic polymers can also serve as smart hydrogel scaffolds, mimicking the natural extracellular matrix for cell cultivation and tissue growth. Ultimately, these developments lead to the creation of biomimetic materials to immobilize bioactive compounds, allowing precise control of cellular adhesion and tissue growth.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GLYCOL) FUMARATE) HYDROGELS; MARROW STROMAL CELLS; PROTEIN SURFACE INTERACTIONS; IN-SITU PHOTOPOLYMERIZATION; ETHER DIBLOCK COPOLYMERS; POLY(ETHYLENE GLYCOL); BLOCK-COPOLYMERS; BIOMEDICAL APPLICATIONS; EPSILON-CAPROLACTONE; OSTEOGENIC DIFFERENTIATION; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Dec 2020 09:05 |
| Last Modified: | 23 Dec 2020 09:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33301 |
Actions (login required)
 |
View Item |
