Castrop, H. (2007) Mediators of tubuloglomerular feedback regulation of glomerular filtration: ATP and adenosine. ACTA PHYSIOLOGICA, 189 (1). pp. 3-14. ISSN 1748-1708, 1748-1716
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In the juxtaglomerular apparatus of the kidney the loop of Henle gets into close contact to its parent glomerulus. This anatomical link between the tubular system and the vasculature of the afferent and efferent arteriole enables specialized tubular cells, the macula densa (MD) cells, to establish an intra-nephron feedback loop designed to control preglomerular resistance and thereby single nephron glomerular filtration rate. This review focuses on the signalling mechanisms which link salt-sensing MD cells and the regulation of preglomerular resistance, a feedback loop known as tubuloglomerular feedback (TGF). Two purinergic molecules, ATP and adenosine, have emerged over the years as most likely candidates to serve as mediators of TGF. Data will be reviewed supporting a role of either ATP or adenosine as mediators of TGF. In addition, a concept will be discussed that integrates both ATP and adenosine into one signalling cascade that includes (i) release of ATP from MD cells upon increases in tubular salt concentration, (ii) extracellular degradation of ATP to form adenosine, and (iii) adenosine-mediated vasoconstriction of the afferent arteriole.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MACULA DENSA CELLS; ACUTE-RENAL-FAILURE; JUXTAMEDULLARY AFFERENT ARTERIOLES; LUMINAL NACL CONCENTRATION; CONDUCTANCE ANION CHANNEL; RECEPTOR-DEFICIENT MICE; NITRIC-OXIDE PRODUCTION; ENDOTHELIAL-CELLS; EXTRACELLULAR ATP; NUCLEOTIDE RECEPTORS; adenosine; adenosine triphosphate; glomerular filtration rate; macula densa; purinergic signaling; renal autoregulation |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Wolf Hayo Castrop |
| Depositing User: | Petra Gürster |
| Date Deposited: | 28 Oct 2020 07:54 |
| Last Modified: | 28 Oct 2020 07:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33306 |
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