Brandl, Ferdinand and Sommer, Florian and Goepferich, Achim (2007) Rational design of hydrogels for tissue engineering: Impact of physical factors on cell behavior. BIOMATERIALS, 28 (2). pp. 134-146. ISSN 0142-9612
Full text not available from this repository. (Request a copy)Abstract
When designing suitable biomaterials for tissue-engineering applications, biological and chemical parameters are frequently taken into account, while the equally important physical design variables have often been neglected. For a rational design of biomaterials, however, all variables influencing cell function and tissue morphogenesis have to be considered. This review will stress the development of crosslinked hydrogels and outline the impact of their physical properties on cell function and tissue morphogenesis. In the first part, the principles of cellular mechanosensitivity, as well as the influence of substrate mechanics on cell behavior, will be discussed. Afterwards, methods to characterize the mechanical properties of biomaterials will be presented. The subsequent chapters will address hydrogels that allow for the control of their physical qualities followed by a discussion of their use in tissue-engineering applications. (c) 2006 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MAGNETIC-RESONANCE ELASTOGRAPHY; EXTRACELLULAR MATRIX-CYTOSKELETON; MOLECULAR-WEIGHT DISTRIBUTION; MECHANICAL-PROPERTIES; NEURITE EXTENSION; IN-VITRO; SUBSTRATE FLEXIBILITY; ALGINATE HYDROGELS; CARTILAGE; STIFFNESS; hydrogel; mechanical properties; degradation; biomimetic material |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 28 Oct 2020 09:45 |
| Last Modified: | 28 Oct 2020 09:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33347 |
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