Hellerbrand, Claus and Bumes, Elisabeth and Bataille, Frauke and Dietmaier, Wolfgang and Massoumi, Ramin and Bosserhoff, Anja K. (2007) Reduced expression of CYLD in human colon and hepatocellular carcinomas. CARCINOGENESIS, 28 (1). pp. 21-27. ISSN 0143-3334,
Full text not available from this repository. (Request a copy)Abstract
CYLD was originally identified as a tumor suppressor that is mutated in familial cylindromatosis. Recent studies suggested a role for CYLD in nuclear factor-kappaB (NF-kappa B) regulation. NF-kappa B activation has been connected with multiple aspects of oncogenesis but the underlying molecular mechanisms of persistent NF-kappa B activation in tumors remain largely unknown. Thus, we evaluated CYLD transcription in different colon and hepatocellular carcinoma cell lines and tissue samples, respectively. CYLD was downregulated or lost in all tumor cell lines investigated as compared with primary human colonic epithelial cells and hepatocytes, respectively. Further, quantitative PCR analysis revealed reduced CYLD mRNA expression in most tumor samples compared with non-tumorous tissue. Analysis on protein level confirmed these findings. Functional assays with CYLD transfected cell lines revealed that CYLD expression decreased NF-kappa B activity. Thus, functional relevant loss of CYLD expression may contribute to tumor development and progression, and may provide a new target for therapeutic strategies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NF-KAPPA-B; CANCER-THERAPY RESISTANCE; TUMOR-SUPPRESSOR GENE; ULCERATIVE-COLITIS; COLORECTAL-CANCER; INFLAMMATION; ONCOGENESIS; ACTIVATION; PATHWAY; TARGET; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Jan 2021 10:15 |
| Last Modified: | 11 Jan 2021 10:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33350 |
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