Cryan, John F. and Slattery, David A. (2007) Animal models of mood disorders: recent developments. CURRENT OPINION IN PSYCHIATRY, 20 (1). pp. 1-7. ISSN 0951-7367, 1473-6578
Full text not available from this repository. (Request a copy)Abstract
Purpose of review The wide spectrum of disruptions that characterizes depression and bipolar illness highlights the difficulties researchers are posed with as they try to mimic these disorders in the laboratory. Nonetheless, numerous attempts have been made to create rodent models of mood disorders, or at least models of the symptoms of depression and bipolar illness. Despite many advances, however, there are no satisfactory animal models available. The need for improved animal models for identifyng new antidepressants and providing insights into the neuropathology underlying the disease is critical. This review focuses on the attempts to improve current paradigms are used to uncover novel molecular targets of antidepressants. Recent findings Currently, there is a shift away from traditional animal models to a more focused research dealing with an endophenotype-style approach, genetic models and incorporation of new findings from human neuroimaging and genetic studies. Summary Endophenotype-based modelling of depression and bipolar illness is opening up more tractable avenues for understanding the neurobiological and genetic bases of these disorders. Further, advances in the clinical dissection of the psychiatric illnesses using molecular genetics, coupled with functional neuroimaging techniques, promises to yield better translational animal models and hence more fruitful therapeutic targets.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ASSESSING ANTIDEPRESSANT ACTIVITY; SUSTAINED ATTENTION-DEFICIT; FORCED SWIMMING TEST; EMOTION PERCEPTION; DEPRESSION; STRESS; MOUSE; BEHAVIOR; RODENTS; BRAIN; endophenotype; genetically modified mice; translational medicine; TREK-1 |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Jan 2021 05:40 |
| Last Modified: | 12 Jan 2021 05:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33389 |
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