Sontag, Thomas A. and Lange, K. W. and Heim, Ch. and Kolasiewicz, W. and Tucha, O. and Sontag, K.-H. (2007) The long-term effects of the neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) on cognitive performance in rats. JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT (72). pp. 149-154. ISSN 0303-6995,
Full text not available from this repository. (Request a copy)Abstract
The neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) has been reported, both in vitro and in vivo models, to produce neurodegeneration and parkinsonian symptoms after prolonged exposure in rats. The aim of the present study was to investigate the effects of TaClo on the cognitive performance of rats. We used the COGITAT hole board system where rats can find hidden pellets by exploring the board. TaClo-treated rats found as many pellets as control rats treated with saline. Furthermore, their search was as efficient as that of control animals since there were no differences between the groups regarding explorative activity, visits to nonbaited holes and time needed to find the pellets. These results suggest that there is no deficit in spatial memory following the chronic administration of TaClo to rats.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PARKINSONS-DISEASE; BASAL GANGLIA; DOPAMINE; NUCLEUS; CORTEX; 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline; TaClo; cognition; spatial memory; COGITAT; rat; Parkinson's disease; animal models |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie I (Allgemeine Psychologie I und Methodenlehre) - Prof. Dr. Mark W. Greenlee |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Jan 2021 10:29 |
| Last Modified: | 12 Jan 2021 10:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33457 |
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