Orth, Stephan R. and Schiele, Guenter and Banas, Bernhard and Ritz, Eberhard and Amann, Kerstin (2007) Effect of a selective endothelin receptor a blocker on cardiovascular remodeling in uninephrectomized spontaneously hypertensive rats of the stroke-prone strain. KIDNEY & BLOOD PRESSURE RESEARCH, 30 (6). pp. 400-407. ISSN 1420-4096,
Full text not available from this repository. (Request a copy)Abstract
Background/Aims: The role of endothelin ( ET) in cardiovascular remodeling was investigated by treating uninephrectomized spontaneously hypertensive rats of the stroke-prone strain ( UNX-SHRsp) on normal- or high (3%)-salt diet with the selective ET A receptor blocker LU 135252. Methods: SHRsp on normal or high salt were sham-operated ( n = 10/ 11) or UNX; UNX received no treatment ( n = 10/ 15) or 100 mg/ kg body weight LU 135252 ( n = 10/ 10). Systolic blood pressure ( BP) was measured weekly. After perfusion fixation the heart and the aorta were analyzed using quantitative morphological and stereological techniques. Results: No effect was seen in normal- salt groups. In high-salt animals UNX caused left ventricular (LV) hypertrophy which was prevented by LU 135252 ( p < 0.001). LU 135252 only lowered BP during the last 2 weeks of the 12-week experiment. UNX showed hypertrophic remodeling of intramyocardial arterioles. Treatment with LU 135252 caused lower wall: lumen ratio and wall thickness of LV intramyocardial arterioles ( p < 0.01). In the descending thoracic aorta UNX caused thickening of the media. The media area and the wall: lumen ratio were lower in UNX + LU 135252 as compared to untreated UNX ( p < 0.01 and p < 0.05, respectively). Conclusion: In SHRsp UNX causes hypertrophic cardiovascular remodeling only in the presence of salt loading. These effects are largely BP-independent and prevented by ET A receptor blockade.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SMOOTH-MUSCLE-CELLS; BLOOD-PRESSURE; RENAL-FAILURE; HYPERTROPHY; HEART; DYSFUNCTION; ANTAGONISTS; NIFEDIPINE; APOPTOSIS; endothelin; hypertrophy left ventricular; arterioles intramyocardial; hypertension; receptor antagonist endothelin; rats inbred SHRsp |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Jan 2021 09:27 |
| Last Modified: | 13 Jan 2021 09:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33469 |
Actions (login required)
 |
View Item |
