Hau, Peter and Kunz-Schughart, L. and Bogdahn, U. and Baumgart, U. and Hirschmann, B. and Weimann, E. and Muehleisen, H. and Ruemmele, P. and Steinbrecher, A. and Reichle, A. (2007) Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-Gamma Agonists in recurrent high-grade gliomas - A phase II study. ONCOLOGY, 73 (1-2). pp. 21-25. ISSN 0030-2414,
Full text not available from this repository. (Request a copy)Abstract
Objectives: Combined treatment approaches targeting tumor as well as other cells contributing to tumor progression may control chemorefractory malignancies. Methods: A phase II trial was initiated to analyze the activity of continuously administered pioglitazone and rofecoxib combined with low-dose chemotherapy ( capecitabine or temozolomide) in patients with high-grade gliomas ( glioblastoma or anaplastic glioma). Results: Fourteen patients were evaluable for response and toxicity. Major side effects were palmoplantar erythema, edema and motor neuropathy grade 3. Disease stabilizations lasting longer than 3 months were noted in 4 of 14 patients ( 29%). Clinical responses did not correspond to immunohistochemical staining for cyclooxygenase 2, peroxisome proliferator-activated receptor- gamma and CD31. Discussion: The study demonstrates that this novel regimen is moderately active and well tolerated in patients with high-grade gliomas. As a comparably small proportion of patients responded, the regimen might only be suitable for a subset of highly selected patients. Copyright (c) 2008 S. Karger AG, Basel.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACTIVATED-RECEPTOR-GAMMA; GLIOBLASTOMA-MULTIFORME; PROGNOSTIC-SIGNIFICANCE; MALIGNANT GLIOMA; CLINICAL-TRIALS; CYCLOOXYGENASE-2; EXPRESSION; APOPTOSIS; CANCER; GROWTH; glioblastoma; anaplastic glioma; low-dose chemotherapy; drug resistance; capecitabine; temozolomide; pioglitazone; rofecoxib |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Jan 2021 11:03 |
| Last Modified: | 13 Jan 2021 11:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33496 |
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