Porsch-Oezcueruemez, M. and Hucke, J. and Westphal, S. and Hubacek, J. A. and Schmitz, G. and Luley, C. (2007) Post-hoc analysis on the CD14 C(-260)T promoter polymorphism and coronary heart disease. PHYSIOLOGICAL RESEARCH, 56 (6). pp. 727-733. ISSN 0862-8408,
Full text not available from this repository.Abstract
Functional C(-260)-> T polymorphism in the promoter of the CD14 gene has been reported to be associated with coronary heart disease (CHD). The functional role of the polymorphism, however, is still a matter of debate, since several. studies have not proved its effect on clinical outcomes associated with atherosclerosis. Cardiovascular-related morbidity and mortality was assessed in a post-hoc approach four years after baseline characterization of patients (male/female n = 36/32) with angiographically proven coronary heart disease. CD14 C(-260)-> T promoter genotype was determined at baseline. Seventeen out of 20 CHD patients with non-lethal cardiovascular events carried at least one T-allele. CD 14 T-260 allele carriers have a 3.59-fold (95 % confidence interval: 1.11-6.75) increased risk for non-lethal cardiovascular events (Kaplan-Meier plot: log rank test p = 0.029). All patients with lethal outcomes (n = 6) were also T-allele carriers. Multivariate logistic regression analysis among CHD patients including age, established risk factors and the C(-260)-> T polymorphism as covariates and non-lethal events as a dependent variable confirmed the independent prospective effect of the T-allele on cardiovascular outcomes in this subset. Further evidence is provided for the role of CD14 C(-260)-> T promoter polymorphism as a genetic susceptibility marker of atherosclerosis in patients with an advanced clinical course of the disease. Due to the small sample size and post-hoc character of the study large-scale prospective studies that monitor patients with proven CHD are needed to confirm these findings.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE MYOCARDIAL-INFARCTION; MONOCYTE RECEPTOR GENE; SERUM-LIPOPROTEINS; KAWASAKI-DISEASE; HEALTHY-SUBJECTS; ARTERY DISEASE; SOLUBLE CD14; RISK; ASSOCIATION; atherosclerosis; CD14; genetics; inflammation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Jan 2021 07:09 |
| Last Modified: | 14 Jan 2021 07:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33554 |
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