Bosch, Oliver J. and Sartori, Simone B. and Singewald, Nicolas and Neumann, Inga D. (2007) Extracellular amino acid levels in the paraventricular nucleus and the central amygdala in high- and low-anxiety dams rats during maternal aggression: Regulation by oxytocin. STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, 10 (3). pp. 261-270. ISSN 1025-3890, 1607-8888
Full text not available from this repository. (Request a copy)Abstract
Brain oxytocin ( OT) regulates aspects of emotionality and stress coping including maternal behavior and maternal aggression. Maternal aggression correlates with the amount of OT released within the paraventricular nucleus ( PVN) and the central amygdala ( CeA). OT, a key neurotransmitter or neuromodulator, is likely to modulate other neurotransmitter systems. Here, we investigated the dynamic changes in extracellular concentrations of the amino acids aspartate, glutamate, gamma-aminobutyric acid ( GABA), serine, histidine, arginine and taurine in the PVN and CeA in lactating rats bred for high ( HAB) and low ( LAB) anxiety-related behavior under basal conditions and during maternal aggression. Further, to determine whether local OT is involved in the regulation of amino acid release we infused a selective OT receptor antagonist ( OTA) via local retrodialysis. Within the CeA, HAB and LAB dams differed in the basal release of glutamate and arginine. Infusion of a selective OTA increased the concentrations of glutamate and aspartate in LAB dams and GABA in HAB dams. In OTA-treated HAB and LAB dams taurine levels increased during maternal aggression. Within the PVN, the highly-aggressive HAB dams showed a more pronounced increase in aspartate and serine levels; the latter being attenuated by local OTA administration. However, OTA did not affect the level of any amino acid in the LAB dams. Thus, the extracellular concentrations of selected amino acids differed between lactating HAB and LAB dams under both basal conditions and following maternal aggression. The effects of OT within the CeA and PVN on maternal aggressive behavior might be related to its regulation of local amino acid release.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | METHYL-D-ASPARTATE; MEDIAL PREOPTIC AREA; LACTATING RAT; NITRIC-OXIDE; SUPRAOPTIC NUCLEUS; BRAIN OXYTOCIN; CONSCIOUS RATS; BEHAVIORAL PARAMETERS; GLUTAMATE RECEPTORS; VASOPRESSIN RELEASE; lactation; rat; hypothalamus; microdialysis; oxytocin receptor antagonist |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jan 2021 06:04 |
| Last Modified: | 15 Jan 2021 06:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33610 |
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