Li, Xiaoqiang and Miltschitzky, Stefan and Grauer, Andreas and Michlova, Veronika and Koenig, Burkhard (2006) Synthesis and peptide-binding properties of a luminescent pyrimidine zinc(II) complex. TETRAHEDRON, 62 (52). pp. 12191-12196. ISSN 0040-4020,
Full text not available from this repository. (Request a copy)Abstract
The synthesis and peptide-binding properties of a Zn(II)nitrilotriacetate complex substituted with pyrimidine hydrazine amides are reported. The metal complex provides millimolar binding affinity in aqueous buffer to peptides bearing N-terminal His. The pyrimidine heterocycles intermolecularly interact with the bound peptide and quench the emission of nearby Trp residues by energy transfer. (c) 2006 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN CARBONIC-ANHYDRASE; PROTEIN CRYSTALLIZATION; AQUEOUS-SOLUTION; AMINO-ACIDS; METAL; AFFINITY; COORDINATION; RECOGNITION; HISTIDINE; LIGANDS; metal complex; peptide binding; histidine; luminescence; pyrimidine |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jan 2021 12:15 |
| Last Modified: | 15 Jan 2021 12:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33644 |
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