Rasappan, Ramesh and Hager, Markus and Gissibl, Anja and Reiser, Oliver (2006) Highly enantioselective Michael additions of indole to benzylidene malonate using simple bis(oxazoline) ligands: Importance of metal/ligand ratio. ORGANIC LETTERS, 8 (26). pp. 6099-6102. ISSN 1523-7060,
Full text not available from this repository. (Request a copy)Abstract
Simple bis(oxazoline) ligands, especially azabis(oxazolines), can catalyze the copper-catalyzed addition of indoles to benzylidene malonates in up to > 99% ee, provided that excess of chiral ligand is avoided. The paradigm followed in many asymmetric catalyses that an excess of chiral ligand with respect to the metal should improve enantioselectivity because a background reaction by free metal is suppressed, is not applicable here, which might call for revisiting some of the many copper(II)-bis(oxazoline)-catalyzed processes known.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FRIEDEL-CRAFTS ALKYLATIONS; ASYMMETRIC CATALYSIS; KINETIC RESOLUTION; COMPLEXES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jan 2021 12:19 |
| Last Modified: | 15 Jan 2021 12:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33646 |
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