Kaftan, H. and Eyrich, D. and Schindler, E. and Goepferich, A. and Hosemann, W. (2006) Fibrin gel for treatment of tympanic membrane perforations. An experimental animal model. HNO, 54 (12). pp. 943-946. ISSN 0017-6192,
Full text not available from this repository. (Request a copy)Abstract
Background. The goal of this study was to evaluate the effects of a fibrin gel on the healing of tympanic membrane perforation in rats. Methods. Prolonged tympanic membrane perforations in 12 rats were created by application of mitomycin C to the intact tympanic membranes followed by bilateral myringotomy. Repeated applications of a fibrin gel to the perforation site of one tympanic membrane were performed in each animal. Tympanic membranes were observed for a total of 8 weeks. Results. One perforation in each group was already patent at the end of the observation period. The mean healing period of the remaining tympanic membranes was found to be 16.7 days in the fibrin gel group and 19.6 days in the control group. Conclusion. A fibrin sheet does not seem to promote the wound healing process of tympanic membranes. However, the sheet might serve as a drug-delivery system for growth factors in the treatment of tympanic membrane perforations, because of its biocompatibility.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FIBROBLAST-GROWTH-FACTOR; MITOMYCIN-C; MIDDLE-EAR; TOPICAL APPLICATION; MYRINGOTOMY; ADHESIVE; tympanic membrane perforation; rat; fibrin gel; mitomycin C |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Jan 2021 07:28 |
| Last Modified: | 18 Jan 2021 07:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33686 |
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