Treatment of pituitary gland hyperfunction. From acromegaly to prolactinoma

Schaeffler, Andreas (2006) Treatment of pituitary gland hyperfunction. From acromegaly to prolactinoma. INTERNIST, 47 (12). 1215-+. ISSN 0020-9554,

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Abstract

Evidence based drug therapy is currently available for the treatment of prolactinomas and growth hormone secreting adenomas ( acromegaly). Dopamine agonists such as bromocriptine, quinagolide or cabergoline represent the standard therapy for the treatment of micro- and macro-prolaktinomas. In pregnancy, more differentiated, individual and patient-adapted therapeutic procedures have to be considered. Transsphenoidal adenomectomy is the treatment of choice for patients suffering from acromegaly. If biochemical cure ( defined by normalized IGF-1 serum levels or by a GH nadir < 1 mu g/l during a 3-h oral glucose tolerance test) cannot be achieved, somatostatin analogues such as octreotide and lanreotide are effective. In some cases, dopamine agonists can be added. In therapy-resistant cases, growth hormone receptor antagonists can be used.

Item Type: Article
Uncontrolled Keywords: HORMONE-RECEPTOR ANTAGONIST; LONG-TERM; SOMATOSTATIN ANALOGS; FOLLOW-UP; CABERGOLINE; THERAPY; HYPERPROLACTINEMIA; PEGVISOMANT; OCTREOTIDE; ADENOMAS; prolactinoma; acromegaly; pituitary gland; dopamine agonist; somatostatin analogues
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Innere Medizin I
Depositing User: Dr. Gernot Deinzer
Date Deposited: 18 Jan 2021 08:00
Last Modified: 18 Jan 2021 08:00
URI: https://pred.uni-regensburg.de/id/eprint/33692

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