Landgrebe, Michael and Marienhagen, Joerg and Langguth, Berthold and Sand, Philipp and Eichhammer, Peter and Hajak, Goeran (2006) Cerebellar and thalamic metabolic changes visualized by [(18)]-FDG-PET in olanzapine-induced acute akathisia. NEUROENDOCRINOLOGY LETTERS, 27 (6). pp. 737-739. ISSN 0172-780X,
Full text not available from this repository. (Request a copy)Abstract
OBJECTIVES: Akathisia is a clinical important symptom, frequently induced by neuroleptic treatment. Despite its clinical importance, less is known about its pathophysiology. METHODS: Using [(18)]-FDG-PET, imaging patterns of cortical metabolic activity were obtained in a patient during olanzapine-induced akathisia and after recovery. RESULTS: Akathisia was characterized by a reduced metabolic activity in thalamus and cerebellum. After discontinuing medication akathisia disappeared, reflected by a recovery of metabolic activity in these brain areas. CONCLUSION: [(18)]-FDG-PET may be useful to identify cortical regions mediating clinical aspects of drug-induced akathisia, thereby offering a deeper insight into the pathophysiology of this serious side effect.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SCHIZOPHRENIA; HALOPERIDOL; akathisia; schizophrenia; positron-emission-tomography; drug-induced side-effects |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Jan 2021 06:08 |
| Last Modified: | 18 Jan 2021 06:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33716 |
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