Okamoto, Hiroaki and Li, Jie and Vortmeyer, Alexander O. and Jaffe, Howard and Lee, Youn-Soo and Glasker, Sven and Sohn, Tae-Sung and Zeng, Weifen and Ikejiri, Barbara and Proescholdt, Martin A. and Mayer, Christina and Weil, Robert J. and Oldfield, Edward H. and Zhuang, Zhengping (2006) Comparative proteomic profiles of meningioma subtypes. CANCER RESEARCH, 66 (20). pp. 10199-10204. ISSN 0008-5472, 1538-7445
Full text not available from this repository. (Request a copy)Abstract
Meningiomas are classified into three groups (benign, atypical, and anaplastic) based on morphologic characteristics. Atypical meningiomas, which are WHO grade 2 tumors, and anaplastic meningiomas, which are WHO grade 3 tumors, exhibit an increased risk of recurrence and premature death compared with benign WHO grade I tumors. Although atypical and anaplastic meningiomas account for < 10% of all of meningiomas, it can be difficult to distinguish them from benign meningiomas by morphologic criteria alone. We used selective tissue microdissection to examine 24 human meningiomas and did two-dimensional gel electrophoresis to determine protein expression patterns. Proteins expressed differentially by meningiomas of each WHO grade were identified and sequenced. Proteomic analysis revealed protein expression patterns unique to WHO grade 1, 2, and 3 meningiomas and identified 24 proteins that distinguish each subtype. Fifteen proteins showed significant changes in expression level between benign and atypical meningiomas, whereas nine distinguished atypical from anaplastic meningiomas. Differential protein expression was confirmed by Western blotting and immunohistochemistry. We established differential proteomic profiles that characterize and distinguish meningiomas of increasing grades. The proteins and proteomic profiles enhance understanding of the pathogenesis of meningiomas and have implications for diagnosis, prognosis, and treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MACROPHAGE ACTIVATING FACTOR; D-BINDING PROTEIN; TUMOR-SUPPRESSOR; ANAPLASTIC MENINGIOMAS; HUMAN GLIOMAS; MALIGNANT MENINGIOMAS; SPORADIC MENINGIOMAS; GENETIC MODEL; CELL-DEATH; NF2 GENE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Jan 2021 09:52 |
| Last Modified: | 20 Jan 2021 09:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33876 |
Actions (login required)
 |
View Item |
